WYE 687
WYE-687
CAS: 1062161-90-3
Molecular Formula: C28H32N8O3
WYE 687 - Names and Identifiers
WYE 687 - Physico-chemical Properties
| Molecular Formula | C28H32N8O3 |
| Molar Mass | 528.61 |
| Density | 1.40 |
| pKa | 13.42±0.70(Predicted) |
| Storage Condition | -20℃ |
| Use | WYE-687 is a potent and ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM. |
| Target | PI3K alpha；PI3K gamma；mTORC1；mTORC2；mTOR；CK1 gamma1；p38 alpha |
WYE 687 - Reference
| Reference Show more | 1: Yu K, Toral-Barza L, Shi C, Zhang WG, Lucas J, Shor B, Kim J, Verheijen J, Curran K, Malwitz DJ, Cole DC, Ellingboe J, Ayral-Kaloustian S, Mansour TS, Gibbons JJ, Abraham RT, Nowak P, Zask A. Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin. Cancer Res. 2009 Aug 1;69(15):6232-40. doi: 10.1158/0008-5472.CAN-09-0299. Epub 2009 Jul 7. PubMed PMID: 19584280. |
WYE 687 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.892 ml | 9.459 ml | 18.918 ml |
| 5 mM | 0.378 ml | 1.892 ml | 3.784 ml |
| 10 mM | 0.189 ml | 0.946 ml | 1.892 ml |
| 5 mM | 0.038 ml | 0.189 ml | 0.378 ml |
Last Update：2024-01-02 23:10:35
WYE 687 - Cell Experiment
For cell cycle analysis, cells are seeded in 96-well culture plates at 10,000 cells per well for 24 hours, treated with various inhibitors for 24 hours or 48 hours. Following treatment, cells are harvested, washed with PBS and fixed overnight at -20 °C in 70% ethanol. Cells are washed, stained with propidium iodide and analyzed for cell cycle profile (acquired 5000 cells/well) on Guava PCA-96 instrument according to the Guava Cell Cycle Protocol(Only for Reference)
Last Update：2023-08-16 21:32:38
Supplier List
Spot supply
Product Name: WYE-687 Request for quotationCAS: 1062161-90-3
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: WYE-687 Visit Supplier Webpage Request for quotationCAS: 1062161-90-3
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: WYE-687 Visit Supplier Webpage Request for quotationCAS: 1062161-90-3
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: WYE-687 Visit Supplier Webpage Request for quotationCAS: 1062161-90-3
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: WYE-687 Visit Supplier Webpage Request for quotation
CAS: 1062161-90-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 1062161-90-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Spot supply
Product Name: WYE-687 Request for quotationCAS: 1062161-90-3
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: WYE-687 Visit Supplier Webpage Request for quotationCAS: 1062161-90-3
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: WYE-687 Visit Supplier Webpage Request for quotationCAS: 1062161-90-3
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: WYE-687 Visit Supplier Webpage Request for quotationCAS: 1062161-90-3
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: WYE-687 Visit Supplier Webpage Request for quotation
CAS: 1062161-90-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 1062161-90-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
WYE 687
降钙素
C.I. Acid Black 24, disodium salt (8CI)
1-Acetyl uracil
488744-96-3
indole-3-pyruvic acid monohydrate
降钙素
C.I. Acid Black 24, disodium salt (8CI)
1-Acetyl uracil
488744-96-3
indole-3-pyruvic acid monohydrate